多种硬化(MS)设计的各种治疗方法:
- change how the disease progresses
- manage relapses
- 帮助症状
MS分为三类MS的疾病修饰疗法(DMTS):
- self-injectable
- 输液
- 口服
Some of these medications can be taken at home, while others must be given in a clinical setting. Each type of medication has certain benefits as well as potential side effects.
有了这么多选择,它很难决定首先尝试哪种治疗。
您的医生可以帮助您权衡每个选择的优缺点以及它们如何影响您的生活方式。
以下了解有关每种药物的信息,请帮助您做出明智的决定。
许多药物注射,女士you can do yourself. You’ll receive training from a healthcare professional and learn the proper way to inject yourself safely.
The Food and Drug Administration (FDA) has approved the following self-injectable medications for the treatment of MS:
- Glatiramer醋酸酯(Copaxone,Glatopa)
- interferon beta-1a (Avonex, Rebif)
- 干扰素Beta-1b(Betaseron,extavia)
- ofatumumab (Kesimpta)
- peginterferon beta-1a (Plegridy)
您可以将这些药物皮下(皮肤下方)注入或肌肉内(直接进入肌肉)。注射可以涉及针或注射笔。
注射频率从每天(某些人服用Copaxone或Glatopa)每月一次(对于那些服用Kesimpta至少3周的人)。
Who should take them?
如果你舒服的自我注射,不喜欢每天服用口服药,可注射治疗可能是您的好选择。
副作用和安全
The side effects of most injectable medications are unpleasant but usually short-lived and manageable.
You may experience pain, swelling, or skin reactions at the injection site. Many of these medications may cause flu-like symptoms as well as liver test abnormalities.
Daclizumab (Zinbryta) is an injectable medication that had previously been used to treat MS. Its manufacturers voluntarily removed it from the global market in 2018 due to concerns about safety, including reports of severe liver damage andanaphylaxis。
在临床环境中静脉内给出输注药物。你不能把它们带到家里,所以你必须能够进入注入。
MS的FDA批准的输注药物是:
- alemtuzumab (Lemtrada)
- 盐酸丝氨酸酮酮
- Natalizumab(Tysabri)
- ocrelizumab (Ocrevus)
输液药物的时间表变化:
- Lemtrada is given in two courses. You receive daily infusions for 5 days. One year later, you receive your second set of infusions, consisting of daily infusions for 3 days.
- 盐酸丝氨酸酮一次每3个月给出一次。
- Tysabri is given once every 4 weeks.
- 前两剂Ocrevus相隔2周。每6个月给出后来的输注。
Who should take them?
如果您在施用药物治疗时想要医疗保健专业人员的帮助,并且不想每天服用药丸,请输液药物可能是您的好选择。
副作用和安全
Common side effects include nausea, headache, and abdominal discomfort. In rare cases, these medications may cause serious side effects such as infection and heart damage.
Your doctor will help you weigh the risks of taking these drugs against the potential benefits.
如果这就是你更喜欢的话,你可能能够以丸形式服用MS药物治疗。
MS的FDA批准的口服药物是:
- Cladribine(Mavenclad)
- 二甲基富马酸盐(Tecfidera)
- Diroximel Mumarate(Vumerity)
- Fingolimod(Gilenya)
- Monomethyl Fumarate(BAFIERTAM)
- Ozanimod(Zeposia)
- siponimod (Mayzent)
- Teriflunomide(aubagio)
Aubagio,Gilenya,Mayzent和Zeposia每天服用一次。Tecfidera和Bafiertam每天服用两次。
In your first week on Vumerity, you’ll take one pill twice per day. Afterward, you’ll take two pills twice per day.
Mavenclad is a short-course therapy.
在2年的过程中,您将有16或20个治疗日。在治疗日,您的剂量将包括一两种药丸。您的体重将确定您的剂量是否含有一两种药丸。
Who should take them?
口服药物are easy to take and are a good option if you don’t like needles.
以规定为本的药物治疗对于它有效,因此如果您服用每日口服剂量,您需要遵循有组织的时间表。
为自己设置提醒可以帮助您坚持安排并按时服用每次剂量。
副作用和安全
口服药物的副作用可能包括头痛和异常肝脏测试。
DMTS以不同的形式提供,如自我注射,输注和口腔治疗。这些表格中的每一个都具有副作用以及益处。
Your doctor can help you choose a medication that’s right for you based on your symptoms, preferences, and lifestyle.