Drug-induced lupus is an autoimmune disorder caused by a reaction to certain medications.

两种药物most often与药物诱导的狼疮相关的是普罗帕因酰胺，用于治疗不规则的心律和高血压医学氢嗪。

服用这些药物并不意味着您会开发药物引起的狼疮。

There are about15,000至20,000个新案件of drug-induced lupus diagnosed each year in the United States, usually in people between 50 and 70 years old.

Symptoms are similar to those of another autoimmune condition called全身性红斑狼疮（SLE）and include muscle and joint pain, fatigue, and rash.

SLE is a chronic condition that can cause inflammation anywhere in the body, including internal organs such as the kidneys or lungs. SLE can be treated, but there’s no cure.

相比之下，药物诱导的狼疮的症状往往很温和，主要器官通常不会受到影响。同样，药物诱导的狼疮是可逆的。症状通常在停止药物后几个月内解决。

与典型的药物副作用不同，药物引起的狼疮的症状不会立即发生。直到您连续服药数月或几年，它们可能不会开始。

Other names for this condition are drug-induced lupus erythematosus, DIL, or DILE.

请继续阅读可能导致狼疮的药物清单，被诊断的方式以及如果有的话可以期望。

If you have drug-induced lupus, your immune system is mistakenly attacking healthy tissue. The resulting inflammation leads to a variety of symptoms. It’s a reaction to continuous use of certain drugs. There areover one hundredreports of drugs having caused drug-induced lupus. The highest-risk drugs are:

  • Procainamide.used to treat irregular heart rhythms
  • 氢化嗪。used to treat blood pressure or hypertension
  • Isonizad.used to treat tuberculosis

其他一些药物moderate-to-very-low风险包括：

抗心律失常

  • Quinidine
  • Disopyramide
  • Propafenone

抗生素

  • 头孢环球
  • minocycline
  • Nitrofurantoin

抗惊厥药

  • 卡马西平
  • Ethosuximide
  • 苯妥英
  • Primidone
  • Trimethadione

Anti量炎性

  • D‐penicillamine
  • NSAIDs
  • 苯丁二酮
  • Sulfasalazine

Antipsychotics

  • Chlorpromazine
  • Chlorprothixene
  • Lithium carbonate
  • Phenelzine

Biologics

  • adalimumab
  • Etanercept
  • IFN -1B
  • IFN‐α
  • IL‐2
  • 英夫利昔单抗

Chemotherapy drugs

  • Anastrozole
  • Bortezomib
  • 环氟酰胺
  • Doxorubicin
  • Fluorouracil
  • Taxanes

Cholesterol medications

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • pravastatin
  • Simvastatin

Diuretics

  • Chlorthalidone
  • Hydrochlorothiazide

高血压和高血压药物

  • Acebutol
  • Captopril
  • Clonidine
  • Enalapril
  • Labetalol
  • methyldopa
  • Minoxidil
  • Pindolol
  • prazosin

Proton pump inhibitors

  • Lansoprazole
  • 奥美拉唑
  • Pantoprazole

Anti-Thyroid medication

  • Propylthiouracil

为什么仅在某些人身上发生这种情况并不清楚，但这可能与这样的因素有关：

risk factors for drug-induced lupus
  • coexisting health conditions
  • 环境
  • genetics
  • interactions with other drugs

There are about15,000至20,000个新案件per yearin the United States, usually in people between 50 and 70 years old.

尽管更多的女性比男性获得系统性红斑狼疮,’s no real difference when it comes to drug-induced lupus. Whites develop drug-induced lupus6次more often than African-Americans, but African-Americans tend to have more severe symptoms.

症状可能直到至少一个月服用该药物之前才开始，但可能需要长达两年的时间。症状因人而异，可能包括：

  • muscle pain (肌痛)
  • 关节痛(arthralgia)
  • pain and discomfort due to inflammation around the heart or lungs (serositis)
  • butterfly rash on the face (疟疾皮疹)
  • red, inflamed, itchy skin rash triggered by sunlight (光敏性)
  • 皮肤上的紫色斑点（紫红色)
  • red or purple tender lumps due to inflammation of fat cells just under the skin (红斑野星)
  • 疲劳
  • 发烧
  • weight loss

Be sure to tell your doctor about all your medications because this is an important clue. A correct diagnosis is crucial because if you keep taking the drug, your symptoms will keep getting worse. It can eventually become life-threatening.

There’s no one specific test for drug-induced lupus. If you have symptoms, your doctor will probably start with a physical exam, including listening to your chest and examining your skin. Depending on your symptoms, you may also have:

  • a blood count and chemistry panel
  • a urinalysis
  • X射线或CT扫描以检查胸部的炎症

A laboratory test called theantinuclear antibody panel (ANA)用于检查您的血液中的组蛋白DNA复合抗体。这些抗体的存在表明诊断出药物诱导的狼疮。有些由于奎尼丁或氢化嗪而导致的狼疮的人可能会测试阴性。

如果您有皮疹，您的医生可以服用纸巾样本。活检可以确认您患有狼疮，但无法区分SLE和药物引起的狼疮。

当狼疮是由于药物引起的时，当您停止服用时，症状应开始清除。如果不是，您的医生可能想排除其他autoimmune disorders.

There’s no specific treatment for drug-induced lupus other than to stop taking the medication. You should begin to improve within a few weeks, though it can take longer for symptoms to go away completely. Generally, no other treatment is needed.

如果您要再次服用该药物，您的症状将会恢复。您的医生将与您合作，找到引起问题的药物的替代品。

Medications

如果症状严重，您的医生可能会考虑开处方皮质类固醇或NSAID来帮助控制炎症。局部corticosteroidscan be used on the skin rash, if needed.

您的医疗保健团队将有哪些医疗专业人员？

In addition to your primary care doctor, you may need to see a specialist to confirm the diagnosis. Depending on your symptoms, these can include:

  • cardiologist: for your heart
  • dermatologist: for your skin
  • 肾脏科医生：肾脏
  • 神经科医生：对于您的大脑和神经系统
  • 肺科医生：为您的肺部

如果诊断是药物引起的狼疮，则需要咨询开处方药的医生，以便找到另一种治疗方法。

Since drug-induced lupus is likely to improve once you stop taking the drug, long-term treatment is usually not necessary.

Natural ways to feel better

如果您有皮疹，那么避免阳光真的很重要。当您出门时，戴着宽桥的帽子来阴影。保持胳膊和腿覆盖，并使用至少55的SPF使用防晒霜。

what you can do to feel better

For overall good health and to help your body recover:

确保给自己额外的休息和放松时间。尝试冥想,deep breathing exercises, or other activities that helpreduce stress.

Continuing to take the drug can become life-threatening.

当您停止服用时，预后通常非常好。症状应在几周内开始缓解，尽管有时可能需要一年时间才能完全解决。

Drug-induced lupus israre. If you take prescription medications and have symptoms of lupus or other药物反应, see your doctor right away.