Breast canceris the
In this article, we’ll go over the characteristics of metaplastic breast cancer, address some easily confused terms, and review treatment options.
Many breast cancers begin in the milk ducts. Under a microscope, the cancer cells resemble ductal cells, but they look abnormal.
Metaplastic breast cancer also begins in the milk ducts. But it looks very different under a microscope. There may be some abnormal ductal cells. But there are also one or more other types of cells in the cancer tissue that aren’t usually found here, like those that make up skin or bone.
Metaplastic breast cancer is usually, but not alwaystriple-negative. This means it lacks estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor 2 (HER2).
Metaplastic tumors tend to be high grade. This means the cancer cells look a lot different from normal cells and reproduce at a high rate. Unlike other types of breast cancer, it’s more likely to be metastatic and spread to the lungs or bones than the lymph nodes.
Symptomsof metaplastic breast cancer are the same as most other types of breast cancer. These may include:
- a lump or thickening on the breast
- change in the size or shape of the breast
- puckering or dimpling of the skin
- nipple turning inward
- nipple discharge
- breast pain
Cancer begins with damage to DNA that allows abnormal cells to grow out of control. It’s not clear exactly why an individual develops breast cancer.
According to theNational Institutes of Health (NIH), there are no known inherited genetic predisposing risk factors for metaplastic breast cancer. The cause for this type of cancer is not known.
Known risk factors for any breast cancer include:
- age —
most breast cancers are diagnosed after age 50 - inherited gene mutations, likeBRCA1 and BRCA2
- personal or family history of breast or ovarian cancer
- first period before age 12 and menopause after age 55
- physical inactivity
- overweight or obesity after menopause
- taking hormone replacement therapy or certain oral contraceptives
- drinking alcohol
Because metaplastic breast cancer is rare, the exact incidence of BRCA1 and BRCA2 mutations isn’t known in this type of cancer.
Metaplastic breast cancer is diagnosed the same way as other types of breast cancer. This may include:
Abiopsyis the only way to confirm a breast cancer diagnosis. After taking a sample of tissue from the tumor, a pathologist examines it under a microscope. The presence of multiple types of cells can suggest that it’s metaplastic breast cancer. Yourbiopsy resultswill contain additional information, like:
- ER, PR, and HER2 status
- tumor grade
Treatment is like that of other types of breast cancer, including both local and systemic therapy. Most metaplastic breast cancers are also triple negative, which means they can’t be treated with hormone therapy. But they’re
Your treatment plan will be based on the features of your cancer, like:
- tumor size
- tumor grade
- hormone receptor (HR) status
- HER2 status
Surgery
Surgery for breast cancer may involve:
- Breast-conserving surgery, also called lumpectomy, is a procedure in which the surgeon removes the tumor and a margin of healthy tissue around it.
- Mastectomyis a surgery that’s done to remove the entire breast.
The type of surgery you choose depends on several factors. These include the size and number of tumors and personal preference.
Chemotherapy
Chemotherapydestroys cancer cells throughout the body and can reduce the risk of spread and recurrence. Chemotherapy can take place before or after surgery.
Radiation therapy
Radiation therapyusually follows breast-conserving surgery to target any cancer cells that may have been left behind. It can also be used following a mastectomy. Radiation can be directed toward the tumor site or nearby lymph nodes.
Drug therapy
Deciding which drug therapy to use depends on the characteristics of the cancer.
Hormone therapyis used to treat HR-positive breast cancers. These drugs help block or stop hormones from fueling the cancer. Metaplastic breast cancer is more likely to be HR-negative, in which case hormone therapy isn’t an option.
Most metaplastic breast cancer is also HER2-negative. But if yours is HER2-positive, you may benefit fromtargeted therapieslike:
- monoclonal antibodies
- antibody-drug conjugate (ADC)
- kinase inhibitors
Gene profiling may help doctors provide more targeted treatments. Researchers have identified various molecular abnormalities that could lead to more targeted therapies. One example of this is a protein called PD-L1.
Researchpublished in 2021 looked at the combination of chemotherapy drugs and pembrolizumab, a PD-L1 antibody. Positive responses to this combination therapy were observed in tumors with intermediate PD-L1 expression.
A2021 case reportinvolved a 72-year-old woman with stage 4 triple-negative metaplastic breast cancer. Her cancer tested positive for PD-L1. She was treated with pembrolizumab for 2 years, during which time she also had surgery. After 32 months, scans showed no evidence of disease, and she maintained a good quality of life.
Metaplastic breast cancer has a poorer prognosis than other breast cancer types. It has
At a median follow-up of 44.5 months, overall survival rates were:
- stage 1:85 percent
- stage 2:73 percent
- stage 3:43 percent
The 3-year overall survival rate for metastatic disease (stage 4) was 15 percent. Outcome was not affected by hormone or HER2 status. Worse outcomes were associated with:
- increasing age
- advanced stage
- lymphovascular invasion
- axillary lymph node dissection vs sentinel node dissection
- no radiation
- no chemotherapy
许多因素影响你的前景。在回顾your tests and medical history, your oncologist can provide you with a more individual prognosis and an idea of what you can expect from treatment.