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  • 一项新的研究发现，服用伟哥的人可能不太可能发展阿尔茨海默病。
  • Experts stress more study is needed to verify the results.
  • 目前，对阿尔茨海默病的疾病没有治愈。

An erectile dysfunction drug, also used to treat high blood pressure, has already shown 承诺 治疗或预防阿尔茨海默病（广告）。

现在，新的研究增加了发现这种众所周知的药物可能有助于降低发展退行性条件的风险。

“After searching [the] literature, we found multiple animal studies showing potential treatment effects of sildenafil in various AD preclinical models,” lead researcherFeixiong Cheng，博士，克利夫兰诊所的基因组医学研究所, told Healthline.

Cheng and team analyzed data from more than 7 million people to find sildenafil (Viagra) significantly reduced the likelihood of Alzheimer’s disease.

According to researchers, their findings, recently 发表 在杂志上老龄化，建议很快就会开门争取痴呆症。

该研究使用了保险数据，大型基因映射网络和综合遗传和其他信息，以发现约1,600名食品和药物管理局（FDA）批准的药物表现出对阿尔茨海默病的有效性。

研究人员专注于靶向两种蛋白质，认为Alzheimer疾病，淀粉样蛋白和Tau标志物的药物，与只瞄准其中一个的药物相比。

据郑，许多药物发现项目仅在过去的20年里失败了。

但对于这个项目，他们测试了一种新的理论，即同时的“双重靶向”淀粉样蛋白和TAU可以为Alzheimer的人提供更好的临床效益。

他解释说，阿尔茨海默病是一种“由许多因素引起的复杂疾病”，而多目标药物或靶向多种疾病途径的组合疗法可能在治疗疾病方面具有更大的益处。

“By testing this novel hypothesis, we identified sildenafil as potential treatment of AD,” said Cheng.

经过一个为期6年的随访后，克利夫兰诊所的研究人员发现，服用西地那非的人比那些没有服用药物的人的疾病的可能性较少69％。

为了进一步检查药物治疗阿尔茨海默病的潜力，成都和团队创建了一种实验室模型，显示了Sildenafil靶向Tau蛋白，增加了脑细胞生长，揭示了药物如何反对退行性条件。

重要的是要注意这项研究没有发现西地那非实际降低了阿尔茨海默病的风险。它只与它有关。程承认有限制因素，表明需要更多研究。

“Although we adjusted many confounding factors in our patient data analysis based on our sizeable efforts, possible confounding factors may exist by our limited clinical knowledge of this complex disease,” he said.

成强烈地强调，在西地那非可以用作阿尔茨海默病的治疗前，必须在临床试验中确认调查结果。

“We are working hard to pursue a RCT (randomized control trial) in the next step,” said Cheng.

“This study looks at data from a very large number of people, but there are several important limitations to consider,”Professor Tara Spires-Jones, DPhil, deputy director of the Centre for Discovery Brain Sciences at the University of Edinburgh, said in a陈述.

据斯派克 - 琼斯介绍，研究数据来自保险索赔，并不是很详细，并不包括关于阿尔茨海默氏症的其他重要风险因素的信息，如性别，风险基因和社会经济地位。

Spiers-Jones指出这些发现有其他可能的解释。

“例如，我们知道大脑发生变化在痴呆症状症状之前的数十年[展示]，并且这些早期的阿尔茨海默氏症的变化可以减少性欲，因此人们不会要求勃起功能障碍的处方，”她解释说。

达杜纳姆布 (Aduhelm) is a recently FDA approved drug to treat Alzheimer’s disease. So far, it’s the only drug approved for this purpose.

它被授予 accelerated FDA approval . This program allows for earlier approval of drugs to treat serious conditions and fill an “unmet medical need” based on a marker, such as laboratory measurement, physical sign, or other measure that might predict clinical benefit.

“亚替曼巴斯不是阿尔茨海默病的治愈，”温斯顿博士, member of the American Academy of Neurology (AAN) Ethics, Law, and Humanities Committee, told thePsychiatric Times.

“这是FDA批准的高成本药物，而无需令人信服的福利和已知的危害，”他指出。

根据威尔神经科学研究所的说法40％of people receiving aducanumab experience brain inflammation called amyloid-related imaging abnormalities (ARIA).

The condition involves brain bleeding, brain swelling, or both.

“Nearly 10 percent of those using the drug will likely need to discontinue their treatment due to concerns related to ARIA,” according to the institute.

Astudy发表in June 2020 found that following at least 4 out of 5 healthy lifestyle behaviors could reduce dementia risk by 60 percent.

The behaviors were:

  • 身体活跃
  • not smoking
  • 适量的酒精消耗光
  • 吃高质量的饮食
  • 精神上活跃

植物为基础Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet是高质量的饮食研究人员推荐。

“This observational study provides more evidence on how a combination of modifiable behaviors may mitigate Alzheimer’s disease risk,” Dr. Richard J. Hodes 是国家老龄化学院主任，在A中说 陈述 .

A new study finds that sildenafil, a drug FDA approved to treat high blood pressure and erectile dysfunction, may reduce the likelihood of developing Alzheimer’s disease by 69 percent.

专家表示，这项研究有严重的局限性，只表现出与风险降低的关联。

They also say that simple lifestyle changes, like not smoking and keeping physically active, could significantly reduce the risk of dementia.